Every paper across the research program, each with its venue, DOI, primary link, and OSF pre-registration where applicable. Indexed on Google Scholar and ORCID; three on arXiv, two on ChemRxiv, three under journal review.
A 1,430-variant parametric search across the developable roller family identifies the oloid as a local optimum under a seven-oracle physics stack. Two-tier invariant vector resolves four linear metrics clustering at 8×10⁻⁷ and three nonlinear fatigue metrics that diverge sharply — evidence the winning geometry does something irreducible to linear contact mechanics.
Computational verification that Sloan's analytical construction does not yield mono-monostatic bodies under the stated parameterization, followed by an extended construction producing a thirteen-member verified catalog. Each catalog member is independently reproduced from open code.
Triply periodic minimal surfaces (TPMS), characterized by the zero-mean-curvature invariant (H = 0), have been proposed as superior heat-exchange geometries. We evaluate this claim under localized Gaussian heat-flux loading using a FEniCS thin-shell surface PDE, parameterized from plasma-torch arc conditions (20 MW/m^2; h = 10^3 - 10^5 W/m^2/K). Under a new single-arc evaluation methodology, peak temperature at the source-attachment point is geometry-independent (~125 K above ambient at h = 10^5 for all tested geometries), confirming that local source physics, not topology, determines peak thermal concentration. The geometry-dependent quantity is mean surface temperature: Diamond TPMS reduces it by 34x over a hemispherical baseline; gyroid by 26x. Rankings are identical across the 100x cooling range and correlate exactly with total surface area (Diamond > Gyroid > Neovius > Schwartz P). The product of mean temperature and surface area is approximately constant, consistent with surface-area-limited thermal advantage. Not all H = 0 surfaces are suitable for all regimes: under gas cooling, Neovius exhibits stochastic material-limit failure in 2% of source positions due to thermal accumulation at narrow channel junctions, demonstrating that the H = 0 invariant alone does not predict thermal performance. Methodological contributions include analytical mean-curvature validation from TPMS implicit equations and FEniCS surface-PDE convergence characterization.
Operationalizes the pre-commit + cascade + amendment-of-record + audit-trail discipline used across the Substrate Geometry program as a reusable methodology for cross-domain computational research. Cascade dispositions fire automatically against pre-committed numerical thresholds, and an audit trail records every amendment of record so that findings surface with their pre-commitment structure intact. Includes a discrete-Gaussian-curvature estimator robustness study (uniform versus mixed-Voronoi normalization; libigl cross-implementation reproducibility to 5.9e-12; a preliminary cross-estimator-family comparison) demonstrating the discipline on canonical roller meshes. The Substrate Geometry papers are the worked examples.
Engineering evaluation of the thirteen-member mono-monostatic catalog under the same physics oracle stack used in the developable roller study. Contact distribution, Hertz stress, thermal, wear, and fatigue compared across the catalog to identify which members are physically viable as rolling-contact primitives.
Three production hERG QSAR models (Pred-hERG LightGBM/ECFP4, ADMET-AI GNN, admetSAR SVM) are stress-tested on an iboga-alkaloid evaluation set with a pre-registered applicability-domain protocol. Two architecture-specific failure modes emerge: GNN + SVM over-call Blocker on designed safer-scaffold analogs (18-MC, tabernanthalog); LightGBM/ECFP4 under-calls Blocker on natural potent blockers (voacangine, noribogaine = DMX-1001 API). Both failures trace to a shared root cause (binding-vs-blockade dissociation) expressing in opposite directions per architecture. The Pred-hERG noribogaine false-negative is shown to be a white-box consensus-rule failure: the binary sub-model correctly calls Blocker; the deployed consensus rule overrides it via the multiclass + regression sub-models. 8 of 8 pre-registered priors landed within their registered probability ranges on the canonical-SMILES rerun.
Across three structurally independent psychedelic compound families (22 tryptamines, 20 phenethylamines, 17 cathinones; 59 compounds spanning natural products to FDA-approved medications), the published primary hERG patch-clamp literature with same-preparation Ki + IC50 pairing yields one substantive datapoint (bupropion, 69 uM). Six of 11 pre-registered priors anticipating training data on marketed pharmaceuticals were falsified in a tightly clustered pattern. A pre-registered targeted retrieval protocol (PubMed bath-salt toxicology, Drugs@FDA bupropion NDA, ergoline boundary spot-check) returned zero additional pairs. Three-architecture cross-architecture positive-call divergence (CAPD) on all 59 compounds clears the pre-registered effect-size threshold on every family; cathinones show 10x spread between ADMET-AI Blocker rate (59%) and Pred-hERG consensus (6%). Two suggestive cross-family cases of the Paper-I consensus-rule override are observed (psilocin and a 4-OH-MET tryptamine analog). The scaffold-vs-bit-level hypothesis resolved PARTIAL CONFIRMATION on the scaffold-aware half. Methodologically the paper adapts PRISMA-S search-protocol-as-load-bearing-methodology to chemoinformatics QSAR-validity work and offers a worked data-landscape-primary template. The empirical finding implies pre-IND cardiac safety triage of psychedelic-class compounds operates against a data infrastructure that QSAR architectures cannot bridge from training to query distribution.
We describe Targum, a controlled-vocabulary translation engine for the esoteric and contemplative primary-source corpus, and report case-study findings from three benchmark passages across two scripts and three traditions. Targum is a layered pipeline (reference resolution, multilingual morphology, hard-constraint glossary, retrieval over a curated scholarly corpus, hermeneutic frame controllers, schema-validated generation, drift audit, registry check, citation verification, and editor sign-off) built over the editorial infrastructure of the Hekhal cross-tradition reference. The architectural design separates the engine (deterministic pipeline) from the scaffolding (per-corpus glossaries, frame controllers, scholarly summaries, and lexicon registries that the engine consumes at generation time). Across three case-study benchmarks (Ibn Arabi Tarjuman al-Ashwaq XI.13-15; the kuntu kanzan Akbarian hadith; Pseudo-Dionysius Mystical Theology I.1) we find that the engine's distinctive value over standard PD translation is realized when the corpus scaffolding is built, and that schema enforcement alone, without a post-LLM existence check against actual infrastructure on disk, produces a failure mode we call vacuous compliance: structurally valid output referencing infrastructure that does not exist. Independent adversarial review of one scaffolded output judged it editor-grade. We argue for a design discipline we call registry-grounded translation: every schema-shape commitment must be paired with a post-LLM existence check against the actual infrastructure.
Computational translation of esoteric primary text presents a problem orthogonal to general-purpose machine translation: the doctrinal content of mystical, contemplative, and apophatic literature is conditioned by the hermeneutic frame the translator brings to the source, and human translation history demonstrates that translators rarely declare the frame they are operating under. We present a single-passage three-reception experiment with the Hekhal Targum engine on the closing of Plotinus's Enneads VI.9.11. The same Greek source is rendered three times under three frame controllers (kataphatic-apophatic, zahir-batin, and a deliberately misapplied PaRDeS as anachronism control), with all other variables held fixed. Four findings: orthographic disposition of the closing monou pros monon tracks frame with each capitalization choice tied in audit trail to a specific frame relation; apparatus density (range cards, cross-references, footnotes) varies systematically by frame and is itself a frame-tracking metric; the deliberately misapplied frame elicits register-decorum awareness from the engine (controller suppressed in body, misapplication flagged in audit trail, cross-tradition resonance surfacing only as homology in apparatus); cross-run experimental design caught a hallucinated MacKenna citation that single-run verification would not have detected. The experiment articulates the methodological position that hermeneutic frame is a tunable, citable parameter of computational translation rather than a hidden default, and that frame-disclosure can be an empirical contribution rather than a philosophical posture.
Three passages from the foundational text of pre-classical Jewish mysticism (Heikhalot Rabbati 1, 19, 24 -- programmatic prologue, seal-passage instructions, throne-approach climax) translated under a new merkavah-ascent frame controller built for the corpus. The first Targum frame for pre-classical Jewish mysticism, surfacing the central modern scholarly debate (Scholem's experiential-ascent reading vs. Schafer's literary-magical reading) honestly in apparatus rather than collapsing to one reading. Hebrew source: Solomon Aaron Wertheimer's Batei Midrashot (Jerusalem, 1893-1897), public-domain globally. The shipment closes a thirty-year gap in publicly accessible Heikhalot Rabbati: the Morton Smith typescript and Davila's Hekhalot Literature in Translation are copyrighted; Odeberg 1928 covers Sefer Heikhalot / 3 Enoch only. Hekhal's namesake corpus finally gets its first canonical translations at full apparatus density.
Composition, pre-registration, and scoping stage. Each entry tracks the load-bearing gate the paper is currently waiting on.
Three connected tests across four primitives (Reuleaux tetrahedron, Meissner M1, Meissner M2, U_3): does the methodology paper's discrete-K bias finding generalize from developable to non-developable singular surfaces; does the Meissner smoothing modification resolve that bias; and within the M1/M2 isovolumetric pair, what local-structural invariants distinguish them. Pipeline A construction via gmsh + OpenCASCADE; Pipeline B via Arman 4D-projection.
Combined BibTeX file for the full publication list, with APA / MLA / Chicago citation formats per paper. Drop the file into your reference manager (Zotero, BibDesk, Mendeley); the entries use stable arXiv / ADS / ChemRxiv / OSF DOIs.
The papers share more than authorship. Each operationalizes the same pre-commit + cascade + amendment-of-record + audit-trail-hash-chain discipline, with cascade dispositions firing automatically against pre-committed thresholds. The methodology paper (forthcoming) enumerates three pre-registration template families with worked examples from this corpus.
See the research-program context